Speciality Requirements Student must complete 54 credit hours

Course Code	Course Name	Credit Hours	Prerequests
7710710	Advanced Hematology	3
This course focuses on enhancement of scientific and technical knowledge in hematology and hemostasis to consult with other healthcare practitioners on the selection of screening and diagnostic tests for hematological disorders, interpretation of results, and recommendations for follow-up testing. Topics to be investigated include physiology and regulation of the hematopoietic system and hemostasis, and the genetic molecular and cellular mechanisms underlying the pathophysiology of selected hematological disorders such as anemias, leukemias, lymphomas, and disorders of hemostasis with additional focus on utilization of appropriatehematology, hemostasis, and molecular diagnostic tests, and reducing turn-around time.
7710711	Advanced Clinical Chemistry and Toxicology	3
This course is designed to familiarize students correlating clinical chemistry and toxicology laboratory results to patient outcomes, associating sensitivity and specificity with laboratory methodologies, and clinician test orders. The student will be given the opportunity to demonstrate an investigatory and analytical thinking approach to clinical situations, including: 1) Development of reasonable and complete differential diagnoses for Chemistry/Toxicology cases based on available clinical information, laboratory tests, and current published information; 2) Discussion of pathophysiology of various diseases, drug metabolites, and metabolic disorders
7710712	Advanced Clinical Microbiology and Infectious Diseases	3
This course is designed to familiarize students with the fundamentals of etiology, pathogenesis, diagnosis and prevention of infectious disease. Initially a brief introduction to microbiology concerning microbial physiology and genetics will be followed by host-parasite interrelationships for specific groups of disease producing agents and appropriate therapeutic agents. Immunologic disorders, as well as the application of immunological principles to diagnoses of diseases, are stressed The student will be given the opportunity to: 1) Develop the laboratory diagnostic and therapeutic interventions necessary for the diagnosis and management of infectious disease; 2) Discuss preventive principles of disease control, prevention of nosocomial infections, and immunization programs: 3) Review the pertinent literature (i.e., textbooks, specific current clinical journal articles and existing electronic databases) regarding specific disease states; 4) Evaluate the pathophysiology, natural history, diagnosis and clinical management of the common or important clinical infectious disease syndromes; 5) Explain the principles of antimicrobial therapy using the functional structure and bio physiology relating to the mechanism of action of antibiotics and antimicrobial agents used in clinical medicine; 6) Utilize various aspects of pharmacokinetics, pharmacodynamics and costs of commonly used anti-bacteria. Prerequisite: admission into Clinical Laboratory Sciences graduate program.
7710713	Advanced Hemostasis	3
This course provides an in-depth study of the physiology and regulation of hemostasis, and the genetic, molecular and cellular mechanisms underlying the pathophysiology of selected disorders of hemostasis. Utilization of appropriate laboratory tests for screening, diagnosis, and monitoring therapy will be discussed and applied through clinical scenarios and case studies. Review of current scientific literature and advanced laboratory practice issues will also be covered.
7710714	Advanced Immunohematology	3
This course focuses on enhancement of scientific and technical knowledge in clinical immunohematology in order to consult with other healthcare practitioners on the identification, resolution, and selection of blood products for rare or multiple blood group system antibodies, interpretation of test results, and recommendations for follow-up testing and transfusion recommendations. Additional topics to be investigated include: therapeutic indications for transfusion, transfusion requirements in special situations, the pathophysiology and investigation of adverse transfusion reactions are also examined, blood utilization management, research in blood component collection and storage, and regulatory agency requirements. Current scientific literature, clinical scenarios, case studies, and advanced laboratory practice issues will be used enhance knowledge and skills.
7710715	Advanced Clinical Immunology and Transplant	3
This course focuses on enhancement of scientific and technical knowledge in clinical immunology and transplantation in order to consult with other healthcare practitioners on clinical applications, diagnostic and therapeutic testing of immune-mediated diseases in autoimmunity, pregnancy, anaphylaxis and allergy, immunotherapy and immunotoxicology, transplantation and HLA testing/compatibility, cancer immunology and immunodeficiency. Topics include test methodologies in cellular, humoral, and molecular immunology, selection and interpretation of test results, and recommendations for follow-up testing for patient monitoring. Current scientific literature, clinical scenarios, case studies, and advanced laboratory practice issues will be used enhance knowledge and skills.
7710720	Advanced Molecular Diagnostics	3
This course focuses on the enhancement of scientific and technical knowledge in nucleic acid-based testing for the diagnosis of acquired and hereditary genetic disorders. Topics include: selection of appropriate screening and diagnostic tests and techniques; results interpretation in the context of other laboratory and clinical data; monitoring disease progression, therapeutic efficacy, and follow-up recommendations; communicating results and providing consultation to healthcare practitioners and other stakeholders in a professional manner including ethical considerations. Current scientific literature, clinical scenarios, case studies, and advanced laboratory practice issues will be used to enhance knowledge and skills.
7710721	Clinical Correlations I	3
This course will correlate clinical presentation and laboratory testing as it relates to physiological changes associated with select diseases of major organ systems (e.g., endocrine, muscle, cardiovascular, respiratory, renal, gastrointestinal, immune, nervous, and reproductive systems).
7710726	Advanced Laboratory Operations	3
This course will explore laboratory quality, utilization, accreditation, regulation, and management topics. Core course content explores the selection, implementation, strengths, and weaknesses of appropriate quality assurance programs to maintain desired quality goals. All aspects of laboratory services will be explored to enhance consultative skills that will be applied in the clinical residency. The use of practice guidelines, critical or clinical pathways, algorithms and reflex testing, direct access testing, evidenced-based practice, and outcomes measurements, as well as initiatives to change the practice of laboratory services in all phases (pre-analytical, analytical, and post analytical) are covered.
7710727	Clinical Correlations II	3
This course will build on 7710721 Clinical Correlations I and will correlate clinical laboratory testing as it relates to physiological changes associated with other diseases of the major organ systems (endocrine, muscle, cardiovascular, respiratory, renal, gastrointestinal, immune, nervous, and reproductive). Diseases will be reviewed with focus on changes in laboratory parameters. Class will include lectures, student presentations, evaluations of research papers, and discussions.
7710735	Seminar I	1
This course prepares the student for the clinical residency. Collegial participation in formal presentations and informal discussion on a variety of topics and issues including, ethical issues in healthcare practice, principles of transcultural healthcare, physical assessment, health informatics, communication techniques for interaction with healthcare colleagues and patients, and heath care informatics
7710736	Seminar II	1
The second course, taken with the clinical residency, and provides a mentored experience focused on refining oral presentation and consultative skills. Learning activities include participation in formal scholarly presentations and informal discussion on a variety of clinical laboratory science research topics and issues, critical review of the current literature, and presenting on Grand Rounds cases. Students will plan and present formal presentations in a scholarly forum based on cases of interest from their clinical practice/residency experiences, literature review, consumer response experiences, and updates on their research
7710737	Clinical Practice Residency I	2
The PhD Core is two courses which provides an in-depth, mentored specialty clinical practice experience. Students complete a one-year clinical residency at an affiliated institution. The supervised clinical residency provides opportunities for students to integrate knowledge and research findings in a practice setting, to develop skills in clinical and management areas, education, research applications, and to interface with other professionals in the healthcare environment. The clinical residency includes: daily grand rounds with the inter-professional healthcare team, participation in interprofessional patient-care conferences, interaction with pathologists, clinicians, patients, medical laboratory scientists, other healthcare professionals, and hospital administrators. Experiences also include clinical laboratory science services at community outreach sites as available and clinical laboratory administrative functions. This structured clinical practice is enhanced with additional experiences individualized for the student and the clinical institution based on identified goals and needs. Through the three-course series, the student will develop competence within the specified practice areas achieving advanced practice skills. Clinical Practice Residency I am the first course, which provides the foundation experiential learning experiences to begin applying advanced knowledge and skills in laboratory diagnosis consultation and interprofessional collaboration directed to quality, cost effective patient care.
7710738	Clinical Practice Residency II	2
Clinical Practice Residency II is the Second course, offered in spring term, which provides the continued experiential learning experiences to further apply advanced knowledge and skills in laboratory diagnosis consultation and interprofessional collaboration directed to quality, cost effective patient care.
7710740	Qualifying Exam	0
7710745	Ph. D. Thesis I*	6
The student will select a scientific problem, design proper research experiments to answer specific questions that have not been answered yet
7710755	Ph. D. Thesis II	6
The student will continue research work, write and defend the thesis.
7710765	Ph. D. Thesis III**	6
The student will continue research work, write and defend the thesis.

Speciality Optional Requirements Student must complete 6 credit hours

Course Code	Course Name	Credit Hours	Prerequests
7710716	Bioinformatics	3
An overview of the newly emerging field of bioinformatics, which is loosely defined as the intersection between the fields of molecular biology and computer science. This course provides an in-depth exploration of bioinformatics analysis of genomic data and the different approaches to mapping and aligning genome sequence data. Student will also learn about programming and scripting along with techniques for the detection and analysis of genomic changes A combination of lecture format and hands-on instruction is provided in the use of, and theory behind, bioinformatics software tools used in genomic and computational biology research. An introduction to the development of bioinformatics software is included, though only basic computer science knowledge is required for this particular course
7710722	Pathophysiology	3
This course focuses on pathophysiology and disruptions in normal body functioning for individuals across the lifespan. In depth theoretical and clinical principles of diseases encountered in primary care setting as well as health disparities resulting from genetic, environmental, and stress related causes are included. Assessment findings, diagnostic testing and interventions specific to selected health problems are explored to begin development of critical thinking skills for pathophysiologic causes and treatments of given disease processes
7710723	Advanced Biostatistics and Epidemiology	3
The emphasis of the course is on the understanding of statistical reasoning in the analysis of epidemiological data and research. Concepts and tools for causation will be discussed. Different types of regression analyses will be described and applied with a focus on application of linear and logistic regression. Other methods such as Poisson regression, Cox regression and survival analysis, multilevel modelling and mediation analysis will also be introduced. The course will also bring up examples of utilization of epidemiological data analysis in research and practice. Epidemiological research articles will be discussed with focus on the statistical and epidemiological methods, and theoretical parts will be illustrated with discussion exercises and computer exercises with epidemiological data.
7710724	Advanced Clinical Pharmacology	3
This course focuses on the clinical application of pharmacology in the management of patients, including frequently prescribed drugs in the health care practice. The basic principles of pharmacodynamics and pharmacokinetics, along with pertinent physiology and information on dosing schedules, therapeutic effects, and adverse reactions are presented. The course content provides web-based discussions, journal review assignments, and case studies/discussion
7710725	Clinical Educational Laboratory	3
7710728	Evidence Based Laboratory Medicine	3
The student will be given the opportunity to 1) discuss the growing need for laboratory evidence, 2) describe the methods and procedures developed in clinical medicine that are used to establish strategies that measure outcomes for diagnosis and disease management and 3) utilize laboratory protocols to illustrate evidence-based laboratory medicine concepts
7710729	Transitional and Outcomes Research in Clinical Laboratory Sciences	3
Methods and techniques for expanding the scientific knowledge base of research, with an emphasis on translational and outcomes research related to the biomedical, clinical laboratory medicine and health sciences fields. The need for translational and outcomes research in clinical laboratory science and multidisciplinary aspects of this type of reach will be explored. Students will be required to write a final paper in a grant proposal format on a specific topic related to clinical laboratory science/medicine or an approved topic related to their proposed graduate project
7710730	Forensic Methods and Techniques	3
This course will be useful to students to well rounded, systematic knowledge and investigation competencies with regard to forensic methods and techniques in the private and public investigation environment. A person credited with this course will be able to conduct investigation in relation to risk analysis, investigation of vulnerable areas, systems or e-resources, investigation with regard to non-compliance with policies. This person will further be able to make recommendations to apply a multi-disciplinary approach, develop prevention strategies to prevent reoccurrence through successful investigations.
7710731	Regenerative Medicine	3
This course provide student with an insight into the current knowledge, future potential use and development of regenerative medicine. Different kinds of stem cells will be discussed as well as tissue engineering and their applications in accelerating the healing process to restore injured or damaged tissues and organs. Basic stem cell biology as well as cellular programming and reprogramming will be covered. Clinical applications of stem cell therapies on diseases, such as e.g. Parkinson's, diabetes and cancer will be discussed as well as cell and gene therapy. Laboratory practicals include in vitro differentiation of neural as well as myeloid stem cells and determination of their specialization using lineage markers assayed by FACS (Fluorescence Activated Cell Sorting) and immunofluorescence.