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Researchers, Professors Ismael Warrad and Mohammad Nouri, from the Department of Chemistry at An-Najah National University, and in cooperation with The University of King Saud in Saudi Arabia, and Karachi University in Pakistan, have received a category American Patent from a patent Publication Center in the United States for their research titled“Heterocyclic Schiff’s Bases as Novel and New Antiglycation Agents.
Background of the Invention
Glycation of proteins plays a role in the process of aging and other disorders, such as diabetes and related complications. It is a spontaneous non-enzymatic reaction, and its rate is accelerated in diabetic individuals due to hyperglycemia, though the reaction occurs in normal individuals as well but at a slower rate. Glycation of proteins in hyperglycemia leads to the formation of Advanced Glycation Endproducts (AGEs) through a complex reaction sequence. Preventing or slowing down the molecular processes of formation of AGEs is considered to be an important approach towards the treatment of late diabetic complications.
Glycation not only involves amino groups of proteins but it also leads to the chemical modifications of basic residues of lipids and nucleic acids. The initial step in protein glycation is the formation of Schiff base in which glucose reacts non-enzymatically with the amino groups of proteins, the labile Schiff base can rearrange itself to a more stable, irreversible configuration known as Amadori product, which ultimately give rise to a poorly characterized heterogeneous group of compounds called advance glycation end products.
The risk factors due to the accumulation and circulation of AGEs include diabetes-specific complications of the micro-vasculature (retinopathy, nephropathy, and neuropathy) and complications of the macro-vasculature systems (atherosclerosis leading to heart disease, stroke and peripheral vascular disease). A number of other problems which are associated with the glycation of biomolecules in hyperglycemic state include chronic vascular complications of diabetes, non-diabetic nephropathy, macrovascular disease, Alzheimer's disease, premature aging, etc.
A large number of heterocyclic Schiff bases are known to exhibit analgesic, antibacterial antifungal, antiviral antipyretic, cytotoxic, anticancer and, antitumor activities. Some of the Schiff bases are also used as chelating agents.
However despite major efforts, no effective antiglycation agent has been introduced in clinical practices. Therefore, there is an urgent need of the systematic research for the discovery of new effective and safe antiglycation agents as potential drugs for the treatment of late diabetic complications.
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Korean Patent House
Stabilization of CdSe thin film electrodes with metalloporphyirin/polysiloxane materices in photoelectrochemical processes.
Mr. Shadi Sawalha, Instructor at the Department of Chemical Engineering at An-Najah, together with Engineer Ayat Atallah and Engineer Haifa Mubaraka succeeded in receiving a patent on their outstanding achievement in designing thermal insulation panels made from recycled paper and recycled low-density polyethylene. The patent was registered at the Department of Industrial Property at the Palestinian Ministry of National Economy.
This patent has been submitted after completing the scientific research of a graduation project that has been submitted in 2009 whose results were of environmental, scientific and economical significance. The importance of the project stems out from the fact that it focuses on getting a product from materials that are considered environmentally harmful if it is not disposed of safely. The final product was cost-effective and with high features that qualify it to become the best alternative for some of the common thermal insulators.
Prior to this achievement, the same team has also won the “Made in Palestine” Award.
Publication number: US20070077428 A1
An odor-inhibiting fiber having a cellulosic fiber and an odor-inhibiting formulation. The odor-inhibiting formulation may contain an odor-inhibiting agent, such as a biocide, an enzyme, a urease inhibitor. The odor-inhibiting formulation also may contain a liquid carrier such as a hydrophobic or hydrophilic organic liquid, or a mixture of a hydrophobic and hydrophilic organic liquid. The cellulosic fiber is impregnated with the odor-inhibiting formulation to produce fiber having odor-inhibiting characteristics. The resultant odor-inhibiting fiber is useful in making absorbent articles with odor-inhibiting characteristics. The fiber of the embodiments prevents odor by inhibiting bacteria growth and ammonia production, especially when used in an absorbent article such as a diaper or adult incontinence device.
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Publication number: US20070254550 A1
A liquid distribution mat that is a wet-laid mat of enhanced cellulosic fibers that are cellulosic fibers cross-linked in sheet form, as well as methods of making the liquid distribution mat. The liquid distribution mat has high vertical wicking properties and excellent structural integrity in both wet and dry states. The liquid distribution mat is suitable for use in an absorbent article. When used in an absorbent article such as a baby diaper, the liquid distribution mat rapidly acquires and transports bodily discharges from the point of insult to other regions of the absorbent article, thereby maximizing the utilization of the absorbent article.
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Publication number: US20060118258 A1
A plasticizing formulation for producing plasticized fluff pulp. The plasticizing formulation, which preferably is an aqueous solution, includes a primary plasticizing agent, and optionally a secondary plasticizing agent. Preferably, the primary plasticizing agent is 1,4-cyclohexanedimethanol, and the secondary plasticizing agent is triacetin. When the plasticizing formulation is applied to a cellulosic fluff pulp, a plasticized fluff pulp is produced. The resultant plasticized fluff pulp may have one or more of the following: reduced Kamas energy, Mullen strength, and fiber knot and nit contents, when compared to the base cellulosic fluff pulp fiber that is not plasticized.
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Publication number: US6844066 B2
The present invention relates to superabsorbent cellulose fiber including cellulose and at least one ethylenically unsaturated monomer. The invention also relates to a method of producing the superabsorbent fiber, and absorbent articles including the superabsorbent fiber.
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Publication number: US20050079361 A1
Embodiments of the invention relate to a modifying agent for making cellulosic based acquisition fibers in the sheet form, the modifying agent being the reaction product of a polycarboxylic acid compound and a polyfunctional epoxy compound. A method of producing the cellulosic based acquisition fiber in the sheet from using the modifying agent includes treating the cellulosic fibers in the sheet form with the modifying agent, and drying and curing the treated sheet to promote the formation of intra-fiber bonding. The resultant cellulosic based acquisition fiber may be utilized in an acquisition layer and/or an absorbent core of an absorbent article.
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Publication number: US20050247419 A1
A treatment composition for producing acquisition fluff pulp, the treatment composition being a mixture of a cross-linking agent and a modifying agent. The cross-linking agent may be a polycarboxylic acid. The modifying agent may be a material that is water soluble non-anionic, non-polymeric material, and can function as debonder and plasticizer. A method of producing acquisition fluff pulp using the treatment composition involves treating a cellulosic base fiber with a treatment composition solution to impregnate the fiber with the treatment composition, and then drying and curing the impregnated fiber. The resultant acquisition fluff pulp may be utilized in an acquisition layer and/or an absorbent core of an absorbent article intended for body waste management.
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Publication number: US20050263258 A1
The present invention relates to cross-linked cellulosic fiber having improved absorbency characteristics when compared to conventional cross-linked fibers. The cross-linked cellulosic fiber is obtainable by reacting pulp in the sheet or fluff form with one or more reagents selected from organic molecule having acid and aldehyde functional groups “acid aldehydes.” The invention also relates to a method of producing the cross-linked fiber. The method includes heating the treated cellulosic fibers to promote intrafiber cross-linking. The cross-linked fibers are characterized by having an improved centrifuge retention capacity, fluid acquisition rate, resiliency, absorbent capacity, absorbency under load, and other absorbent properties. The inventive cross-linked fibers are useful in forming absorbent composites, and in particular absorbent cores for use in absorbent articles.
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